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This talk will focus on the design, synthesis, and evaluation of different 1D, 2D, and 3D glycosylated architectures for targeting pathogens. The scientific approach to developing different glycosylated systems is based on the topological understanding of viruses and bacterial surfaces, their cell binding phenomena, and the infection cycle. Recently published articles on different topics in the area of anti-pathogenic glycoarchitectures will be discussed. These include low molecular weight glycosylated polymers dropping viral infections at early and late stages of infection, virus and bacteria adapting nanogels, and sheet-like materials for blocking or trapping viruses and bacteria.