Responsible: Dra. Mónica Calera Medina
Research lines
a)Research the cellular mechanisms regulated by adhesion proteins, caderinas, in the invitro formation process of blood vessels (angiogenesis). This area of research is interesting, not only for the studies physiologic and biochemical processes but also for the treatment of illnesses like cancer, inflammation and cardiovascular diseases.
b) Determine the participation of communicated unions or gap junctions on the cellular adhesion processes an the damage to the DNA caused by different types of stress.
c)Research and characterize the function role of the GTPases Gpn in 1/ on different cellular processes.
Publications
Rogelio González-González, José A. Guerra-Moreno, Gema R. Cristóbal-Mondragón, Violeta Romero, Sonia G. Peña-Gómez, Gabriela M. Montero-Morán, Samuel Lara-González, Andrés Hernández-Arana, Daniel A.Fernández-Velasco, Mónica R. Calera, Roberto Sánchez-Olea (2017). Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail. Protein Expression and Purification 132:85-96
Gehenna Guerrero-Serrano, Leonardo Castanedo, Gema R. Cristóbal-Mondragón, Javier Montalvo-Arredondo, Lina Riego-Ruíz, Alexander DeLuna, Alejandro De Las Peñas, Irene Castaño, Mónica R. Calera, Roberto Sánchez-Olea (2017). Biochimica et Biophysica Acta - Molecular Cell Research 1864(3):451-462
Lucía E. Méndez-Hernández, Ana E. Pérez-Mejía, Bárbara Lara-Chacón, Angel A. Barbosa-Camacho, Sonia G. Peña-Gómez, Mayra Martínez-Sánchez, Angélica Y. Robledo-Rivera, Roberto Sánchez-Olea, Mónica R. Calera (2014). Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells. FEBS Letters 588 (21):3823-3829
Humberto Reyes-Pardo, Angel A. Barbosa-Camacho, Ana E. Pérez-Mejía, Bárbara Lara-Chacón, Leslie A. Salas-Estrada, Angélica Y. Robledo-Rivera, Gabriela M. Montero-Morán, Samuel Lara-González, Mónica R. Calera, Roberto Sánchez-Olea (2012) A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear tageting of RNA polymerase II, is necessary and sufficient for nuclear export. Biochimica et Biophysica Acta –Molecular Cell Research 1823(10):1756-1766
Mónica R. Calera, Cristina Zamora-Ramos, Minerva G. Araiza-Villanueva, Carlos A. Moreno-Aguilar, Sonia G. Peña-Gómez, Fabiola Castellanos-Terán, Angélica Y. Robledo-Rivera, Roberto Sánchez-Olea (2011). Parcs/Gpn3 is required for the nuclear accumulation of RNA polymerase II. Biochimica et Biophysica Acta - Molecular Cell Research 1813(10):1708-1716.
Calera, M.R., Wang, Z., Sánchez-Olea, R., Paul, D.L., Civan, M.M., y Goodenough, D.A. (2009). Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci. 50(5):2185-2193.
Sánchez-Olea, R., Calera, M.R., Degterev, A. (2009). Molecular pathways involved in cell death after chemically induced DNA damage. Molecular, Clinical and Environmental Toxicology 1: 209-229.
Franco, R., Sánchez-Olea, R., Reyes-Reyes, E.M., Panayiotidis, M.I. (2009). Environmental toxicity, oxidative stress and apoptosis: Ménage a trios. Mutation Resarch/Genetics Toxicology and Environmental Mutagenesis 674: 3-22
