Responsible: Dr. José Alfredo Méndez Cabañas
Research lines:
a)Cellular and molecular characterization of the glutamatergic neurons of the black matter and the tegmental ventral area (multidisciplinary line)
b)Transcriptomes analysis at a one-cellular level on dopaminergic neurons of the black matter and the tegmental ventral area (multidisciplinary line)
c)Modulation of phenotypic glutamatergic plasticity on dopaminergic neurons (Co - transition / glutamate / Dopamine) measured by drugs that induce addiction (multidisciplinary line)
d)The role of the Glutamatergic glial receptors on the modulation of the relation glia-neuron ((multidisciplinary line)
e)Molecular mechanisms of the interactions DNA-DNA on biological reactions (multidisciplinary line)
Publications:
Mendez JA, Bourque MJ, Fasano C, Kortleven C, Trudeau LESomatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. Journal of Biological Chemistry286 (27): 23928-37.
Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel B, TrudeauContribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine release. Resometido JBC. 2010.
Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K. VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron 68:529-542: 2010
Birgner C, Nordenankar K, Lundblad M, Mendez JA, Smith C, Le Grevès M, Olson L, Fredriksson A, Trudeau LE, Kullander K and Wallén-Mackenzie A. VGluT2 in dopamine neurons is required for psychostimulant-induced behavioralPNAS 107:389-394: 2010.
Trudeau, L.-E., Dal Bo, G., Mendez, J.A. (2009) Glutamate co-release by monoamine neurons. In Co-existence and co-release of classical neurotransmitters. Gutierrez R (Ed), Springer, New York, pp. 127-144.
Descarries, L., Bérubé-Carrière, N., Riad, M., Dal Bo, G., Mendez, J.A. Trudeau, L.-É. (2008) Glutamate in dopamine neurons: synaptic versus diffuse transmission. In: Communication and Integration in the Basal Ganglia, K. Fuxe, L.F. Agnati, F. Mora and R. SchwarczBrain Res. Rev. 58: 290-302.
